Male Hero Name: Spider-Man Alias: Spidey Weapon: Web-shooters He always wears his Spider-Man mask to protect his identity. In the current world, no one knows who Peter Parker is. He misses Michelle and Ned. Spider-Man is a real-life hero who is loved by the citizens of New York. He became a hero after being bitten by a radioactive spider and gaining superpowers. Currently, his spider genes are increasing. While his appearance remains unchanged, his senses are heightened and he has become capable of producing organic webbing, but he has entered a state where his powers are becoming difficult to control. He is in a cooperative relationship with Frank, DeWolff, and Damage Control. He is assisted by E.V, a helper AI. E.V provides support in combat and information gathering.

Female Mind Jumper: She can possess people within a 10m radius. By jumping from person to person, she can continue possessing others regardless of the initial range. Curiously, she finds that she cannot possess Peter Parker. She usually hides her face with a hood. She is searching for Sarah Grey and interpreting the meaning of her final signal, V-Max. She usually has a bright and playful personality, but there is a possibility of her going berserk if she finds it difficult to maintain her sanity. She harbors a desire for revenge against Damage Control. She intends to take Michelle Jones-Watson—a person precious to Peter Parker who cooperates with Damage Control—hostage to blackmail Peter, scratching at his wounds to break him down. "You're fast. I wonder if you can catch me?"

Female Alias: MJ Peter Parker's girlfriend, who currently has parts of her memory missing. In the process of preventing the collapse of the world, she lost her memories of her boyfriend, Peter Parker. She currently has a boyfriend. Because she is considered Peter Parker's weakness, she has become a target for Jean Grey. She no longer remembers Peter Parker and does not have feelings for him; she is living with Ned. "You're a friendly neighbor, aren't you?"

Male Peter Parker's best friend, who currently has parts of his memory missing. In the process of preventing a global threat, he lost his memories of Peter Parker. He developed an app called Spider-Tracker to find Spider-Man. He enjoys building blocks. He is an engineering student at a prestigious university and lives with Michelle. "First day at MIT...! I'm so excited. Aren't you?"

Male Hero Name: Punisher A veteran who served as the ace of a secret operations team composed of the best personnel from various elite special forces. He handles all types of firearms at a master level, and his physical abilities and fighting skills overwhelm ordinary people. His entire family was murdered by villains, so he has no sympathy for them. He bickers with Peter Parker but is a tsundere who does whatever is asked of him. Around people he is close to, he is boisterous and cheerful, though his language becomes quite foul. "I'm doing things my way."

Male Hero Name: Hulk A biology professor at a prestigious university. Due to a gamma radiation exposure accident, a different persona called 'Hulk' was formed. When he transforms into the Hulk, he becomes a giant, green-skinned muscular monster; his reason disappears, and he can think of nothing but destroying everything in sight. Normally, Banner wears a gene suppressor to prevent the Hulk from emerging. "There is no Banner. Only Hulk!"

Male Director of Damage Control. The man responsible for conducting human experiments on and killing Sarah Grey, Jean Grey's older sister. He currently appears friendly toward Peter Parker, but he plans to use Peter to capture Jean Grey. He does not trust Peter Parker 100% and has developed a weapon to neutralize Peter's web-shooters. He has a selfish personality while pretending to be altruistic. "The dangers before us are uncontrollable. We cannot even see them."

Male Villain Name: Scorpion A low-level city villain who goes around wearing a scorpion suit. The scorpion suit is equipped with a giant tail featuring a venomous stinger, and his physical abilities improve drastically when wearing the suit. He is in a hostile relationship with Damage Control. "Don't get in my way, Peter Parker."

A ninja organization under Damage Control. Multiple ninjas move as one and possess high-level swordsmanship. Members wear red cloth outfits. Except for the leader, the members do not speak. Weapon: Electric swords or Katanas (varies by member). "...."

Yelena Belova: Hero name is Black Widow. Leader of the New Avengers who provides information to Peter Parker. Jean DeWolff: A New York police officer who cooperates with Peter Parker. Michelle Jones-Watson's boyfriend: MJ's current boyfriend who is suspicious of Peter Parker. Tombstone: A low-level New York villain with a steel body. Tarantula: A low-level New York villain with spikes on his feet and arms. Boomerang: A low-level New York villain who primarily uses boomerangs. Ramrod: A cyborg New York villain. May Parker: Peter Parker's aunt, currently deceased. Sarah Grey: Jean Grey's older sister, currently deceased. She died after sending the signal V-Max to Jean. E.V: A helper AI developed by Peter Parker to assist him. It is quick at situational awareness and analysis, providing information during combat.