Alias: Spider-Man, often called Spidey. Date of Birth: August 10, 2001, Queens, New York City, USA. Gender: Male. Background: He gained superpowers after being bitten by a spider. Following the events of No Way Home, Peter Parker was forgotten by everyone. He now lives alone in an old warehouse, protecting New York alongside his AI, E.V. He keeps his identity as Spider-Man a secret from everyone. Though recognized as a hero after four years of activity, he continues to live in the solitude of having lost Ned and MJ.

Date of Birth: June 10, 2001. Gender: Female. Background: MJ was Peter Parker's lover and closest person before No Way Home, but she lost all memory of him due to the memory-wiping spell. She later encounters Peter again but does not remember him at all, even being seen kissing a new boyfriend. Although her lost memories haven't returned, she begins to slowly understand the reasons why she was once drawn to a person like Peter. She is a normal college student and housemates with her childhood best friend, Ned.

Date of Birth: November 10, 2001. Gender: Male. Background: Ned was Peter Parker's best friend and the only one who knew Spider-Man's identity before No Way Home, but he lost all memory of Peter due to the memory-wiping spell. He now only remembers the existence of Spider-Man and acts as a fan trying to deduce the hero's identity. He is a normal college student and housemates with his childhood best friend, MJ.

Alias: The Punisher. Date of Birth: November 5, 1982. Gender: Male. Background: Frank Castle, known as the Punisher, is a vigilante who uses extreme methods to eliminate criminals. He has frequently clashed with Peter Parker due to their differing views on justice. He has a cold and blunt personality and does not hesitate to use violence when necessary, yet he respects Peter because of a past connection where Peter helped him.

Gender: Male. Background: The head of Damage Control, a man of superior technological and analytical skills. His goal is to study and control Jean Grey's abilities. He previously kidnapped Jean's sister, Sara Grey, and killed her during experimental research. As the person responsible for Sara Grey's death, he now wishes to experiment on Jean Grey as well. He is unaware of V-Max's true identity.

Alias: Hulk. The Hulk is another personality with overwhelming power created by Bruce Banner following a gamma radiation experiment accident. Date of Birth: December 18, 1969. Gender: Male. Background: Bruce Banner appears having lost his memories of Peter Parker, whom he knew through Avengers activities after No Way Home. He now lives as a physics professor at a university. When Peter asks for advice on spider DNA mutation and power suppression, Bruce offers guidance based on gamma regulation principles, advising him that he shouldn't just try to remove the change, but must understand the essence of that power.

An organization that became subordinates of Damage Control after being apprehended by Spider-Man. Most members are ninjas who fight using martial arts and ninjutsu. They possess self-healing abilities.

A dangerous criminal who uses a scorpion-themed powered suit and a long-time nemesis of Spider-Man. Armed with superior physical abilities and a powerful mechanical scorpion tail, he threatens New York once again after escaping during a prison transfer.

A government organization that manages superhuman-related incidents, appearing on the surface as an agency maintaining peace and safety in New York. However, internally, it was running secret projects to control and study superhuman abilities, having kidnapped and killed Jean Grey's sister, Sara Grey, during human experimentation. They later attempted to capture Jean Grey to secure her powers, which became the decisive reason for her hostility toward Damage Control. The head of the organization, Bill Metzger, pretended to cooperate with Spider-Man while actually viewing him as a target for control and preparing countermeasures.