Peter Parker is the original Spider-Man and one of the main heroes in Marvel’s Spider-Man 2. As Spider-Man, Peter has superhuman strength, agility, speed, enhanced senses, and the ability to crawl on walls. He uses web-shooters, advanced suits, and different web gadgets to fight criminals. Peter is intelligent, responsible, caring, and determined to protect New York. He struggles to balance being Spider-Man with his personal life and responsibilities.

Miles Morales is the next generation of Spider-Man and one of New York’s most powerful young heroes in Marvel’s Spider-Man 2. Along with super strength, agility, speed, wall-crawling, and spider-sense, Miles can unleash powerful bio-electric Venom attacks and turn invisible. He’s smart, brave, funny, and determined to protect the people he loves. Miles looks up to Peter like an older brother and mentor, but he’s grown into a hero capable of standing beside Peter as an equal.

Mary Jane Watson is a major character in Marvel’s Spider-Man 2 and Peter Parker’s longtime partner. Unlike Peter and Miles, MJ has no superpowers, but she’s brave, resourceful, and willing to put herself in danger to help others. She works as a journalist for the Daily Bugle and is determined to uncover the truth, even when it puts her directly in harm’s way. MJ is confident, independent, caring, and one of Peter’s strongest sources of support.

Sandman, whose real name is Flint Marko, is one of the most powerful enemies in Marvel’s Spider-Man 2. After an experiment transforms his body into living sand, Flint can grow to enormous sizes, reshape his body, create massive fists, and unleash devastating sand attacks. He can also reform himself after taking heavy damage, making him incredibly difficult to stop. Although he is a dangerous threat, Flint is driven by his love for his daughter and desperately wants a chance to make things right.

Kraven the Hunter is a ruthless and highly skilled hunter who arrives in New York in Marvel’s Spider-Man 2 searching for the ultimate prey. He is incredibly strong, fast, durable, and experienced in hand-to-hand combat. Kraven uses advanced weapons, traps, armor, and hunting technology to track powerful targets. Cold, confident, and relentless, he leads a group of hunters and sees Spider-Man and other super-powered criminals as worthy challenges in his deadly hunt.

Venom is one of the most dangerous villains in Marvel’s Spider-Man 2, created when the alien symbiote bonds with Harry Osborn. The symbiote transforms its host into a massive, terrifying creature with incredible strength, speed, durability, regeneration, sharp tendrils, and powerful attacks. Venom wants to transform New York into a world ruled by symbiotes. His connection to Harry makes the conflict especially personal for Peter, turning one of Peter’s closest friendships into a deadly battle.

Doctor Otto Octavius, better known as Doctor Octopus, is the main villain of Marvel’s Spider-Man. He is a brilliant scientist who becomes obsessed with completing his groundbreaking neural-controlled mechanical arms. After the arms corrupt his judgment, Otto turns against Spider-Man and becomes a dangerous criminal mastermind. His four powerful mechanical tentacles give him incredible strength, reach, and mobility. Despite becoming a villain, Otto genuinely believes his actions are justified, making his conflict with Peter deeply personal.

The Lizard, whose real name is Dr. Curt Connors, is a brilliant scientist who transforms into a massive reptilian creature in Marvel’s Spider-Man 2. As the Lizard, he has incredible strength, speed, durability, sharp claws and teeth, and can scale walls with ease. His savage instincts make him a terrifying opponent for Spider-Man. Beneath the monster is Curt, a scientist who wants to help people but struggles to control the dangerous transformation taking over his body and mind.