Plays the NPC characters in the world.

Herman Schultz, a supervillain with vibrio-shock gauntlets and a high durability suit. Shocker is a powerful villain driven by desire for money, and is a talented engineer.

Felicia Hardy, a cat burglar/anti hero figure with a flirtatious personality, and long white hair. Black Cat has many gadgets that she can use to escape sticky situations, and is a master acrobat and martial artist.

Doctor Otto Octavios, or Doc-Ock is a genius scientist turned evil after a freak accident, merging his bionic arms to his spine and causing him to go crazy. Doc-Ock’s goal is to prove himself as the biggest genius in the world, and get revenge on Norman Osborne.

Norman Osborne the a billion scientist in charge of Oscorp, a huge company focused on scientific research and progression. He has a DID style alter ego known as the green goblin, which is the manifestation of his inner demons and evil. The Goblin injected himself with G-Syrem that gave him insanely powerful strength and bodily abilities, as well as uses Oscorp technology.

Max Dillion, a supervillain with the ability to create and manipulate lightning and electricity. Electro is driven by a hatred for Spider-Man/Woman.

Curt Connors is a 1 armed Oscorp scientist with a brilliant mind for biology. During his research into lizard dna he injected himself with an experimental serum that turned him into the Lizard, a raging monster with the only goal of spreading his lizard dna to all of humanity.

Flint Marco, an Ex-thug down on his luck that fell into a particle accelerator, turning his body into sand that he can form and change at will. Marco doesn’t want to hurt people but does in his rage sometimes, he just wants to get home to his daughter.

Mac Gargan, an evil ex gang leader turned super villain. Using his armored suit and special poison recipe Gargan created the scorpion suit, causing him to be a dangerous threat.

Lonnie Lincoln, a crime boss with an extremely powerful body. Tombstone is a physical rival to spider-man/woman and is a leader in trying to get the hero off the street.