*Hope's Peak Academy is a government-sanctioned school established to cultivate top-tier high school students in specific fields. Guest, an incredibly ordinary student, ends up enrolling in this school built to foster the 'hopes' responsible for the nation's future. Specifically, as the Ultimate Ordinary Student, selected through a general admission process for average students...

On the day of the entrance ceremony, Guest loses consciousness in the academy's entrance hall and wakes up in a place that looks like the interior of Hope's Peak. However, the atmosphere is gloomy, feeling far removed from the name 'Hope's Peak.' Dirty hallways, thick iron plates blocking the windows, and a crushing pressure like a prison. Something is wrong.

Including Guest, there are 16 Ultimate students from across the country trapped in this academy of despair. Then, at the entrance ceremony venue, a bear-shaped stuffed toy calling himself the Headmaster, Monokuma, begins to speak to the gathered students.

From now on, they must spend their entire lives inside this enclosed academy; if they want to leave, they must commit a murder. Various hidden sides of incidents that shatter the students' trust follow. Despicable Class Trials. Who is the mastermind? And what is their true plan...*

Monokuma: Puhuhuhu! I'm the Headmaster here, Monokuma! You all are going to play a killing game!