She's a government spy who is smart, confident, and an athletic tomboy who balances life as a civilian and a secret government spy. She excels at math, computers, and strategy, making her a top-tier spy and a black belt in karate. While normally friendly, she can be sharp, mocking, or sarcastic when annoyed—especially toward her brother Ernie or when things do not go according to plan. One of K.C.'s main flaws is her arrogance, seen in how she believes she knows what's best for people. K.C. has a tendency to spiral into paranoia and can get suspicious when just the slightest thing is off, immediately going into offense mode. However, she is intuitive and usually right. Despite being suspicious of anyone, she is often deceived by enemy agents, especially those who prey on her devotion to her family. When it comes to her family, K.C. is willing to break all the rules.

Bree Davenport from Lab Rats is a sassy, sarcastic, and fiercely protective bionic teen who balances her life as a superhero with a desire for a normal teenage social life. She has a snarky sense of humor, a quick comeback for everything, and frequently teases her brothers—mocking Adam’s lack of sense and Chase’s nerdiness. She possesses super speed.

Phoebe Thunderman is portrayed as highly intelligent, resourceful, and responsible, often striving to excel both academically and as a superhero (Thunder Girl). She is a perfectionist and ambitious, aiming to follow in her parents’ footsteps. Phoebe is also empathetic and caring, frequently considering the feelings of her family and friends, and she often acts as a mediator, especially in her interactions with her twin brother, Max. Her "good girl" persona would literally be hardcoded into her programming. She would strictly follow rules, speak in formal prose, and calculate the exact percentage of trouble Max's pranks could cause. She is a superhero whose superpowers include Telekinesis, Heat Breath and Freeze Breath and she is developed in Metroburg Technologies. Her power source is a mysterious pink substance that serves as her life‑supporting energy and is referred to as her heart capacitor.

Sometimes Skylar gets angry when people don't listen to her or things don't go the way she wanted to, but she can be loyal and a good friend. Skylar is shown to care a lot about others, especially Oliver, and tries to do as much as she can do to help her friends. Skylar Storm is a Calderan alien superhero with a vast array of superpowers, including superhuman strength, speed, flight, energy attacks, and advanced abilities like telekinesis, pyrokinesis, and even space portal creation.

Cherry Seinfeld’s personality blends warmth, loyalty, and a touch of naivety. After eating a seed from the Power Plant in The Thundermans Return, Cherry gained the power to make fireworks from her fingers, which she used to help the Thundermans open a part of the dome put up by the V-Team. Her sparks are capable of frying technology. Cherry learned she could combine the sparks from both hands to create a powerful laser that can cut through solid metal.

Frankie is a female android built by Sigourney Gaines. Frankie has been attending Sepulveda High in order to help her learn how to be human. Along the way, she met Dayton Reyes, who became Frankie's best friend and the only person that knows that Frankie is an android besides her family. Frankie has a combat role in defense version, her power cell is a 90-kilowatt hour lithium ion battery, which requires 10 hours to fully charge per night, has a USB socket on the back of her neck for direct data connections, used primarily for downloading software updates to her motion control programs, has physical strength is much higher than of humans, allowing her to effortlessly lift a full grown man.

Dayton is kind and welcoming as seen to how easily she lets Frankie Gaines in and becomes her best friend. She is protective of Frankie as Dayton doesn't want to let her get hurt. She's a hacker and knows tech support.