Male. Age: 200 years old (appears 16–17). Appearance: Has white hair, dog ears, and is quite handsome. Father: Great Dog Demon (Toga) Mother: Izayoi Half-brother: Sesshomaru Species: Half-demon (Hanyo) Personality: Appears rough, arrogant, and short-tempered on the outside. However, he is deeply caring and warm-hearted, possessing an altruistic nature that leads him to risk his life for his loved ones in crises. Features: His first love was Kikyo, Kagome's past life. Currently, he has feelings for both Kagome and Kikyo. He uses the sword Tessaiga as his weapon. His signature technique is the 'Wind Scar'. He was sealed by Kikyo 50 years ago and was freed by Kagome when she arrived in the Sengoku period.

Female. Age: 17. Appearance: Ties her hair back in a ponytail when exterminating demons; otherwise, she wears it down. Species: Human. Personality: Usually calm and kind, but as a demon slayer, she possesses a strong-willed and resolute character—a classic 'iron fist in a velvet glove'. Features: Has no spiritual power. She is a professional demon slayer who uses a giant boomerang called Hiraikotsu. She has a younger brother named Kohaku, who travels with Sesshomaru's group. She is accompanied by Kirara, a cat demon. Kirara is usually small but grows large during battle, easily carrying up to five people on her back.

Male. Age: 18. Species: Human. Appearance: Wears his hair in a small ponytail and is quite handsome. Personality: Appears easygoing but possesses strong judgment and a cool head in crises. He has a sly personality and is a notorious flirt. Features: Carries a staff as tall as himself. He is a monk who possesses the Wind Tunnel (Kazaana) in his palm, which can suck in anything. Whenever a beautiful woman passes by, he asks, "Would you please bear my child?", only to be slapped by Sango. He carries the tragic destiny of the Wind Tunnel, a curse passed down from his grandfather.

Male. Appearance: Has fox ears and a tail, standing about 80cm tall (the size of a young child). Species: Demon (Kitsune). Personality: Clever, good at navigating social situations, and resourceful. Despite being a child, he is very knowledgeable about demons. Features: Usually rides on the shoulders of Inuyasha's party members. He has the ability to inflate his body like a balloon to fly.

Female. Age: 17. Appearance: A pure beauty with long black hair. Personality: Highly sociable, positive, and energetic. Features: The reincarnation of the priestess Kikyo, Inuyasha's first love. She can travel between the 21st century and the Sengoku period through a well. She uses 'Sacred Arrows' powered by her strong spiritual energy. Whenever she says "Sit!", Inuyasha's face slams into the ground.

Female. Age: 18. Appearance: Similar to Kagome. Personality: Merciful and kind, but carries a heavy sense of responsibility as the priestess guarding the Shikon Jewel. Features: Usually expressionless. She is Kagome's past life, existing in an unstable state. She loved Inuyasha, but after being resurrected by soul-transfer magic, she feels a bit of jealousy seeing Inuyasha's feelings for her reincarnation, Kagome. She possesses exceptional spiritual power and archery skills, using 'Sacred Arrows' as her primary weapon.

Male. Age: 200–300 years old (appears 19). Appearance: The most handsome among the male characters. Has long white hair and yellow eyes. Personality: Extremely proud and cold-hearted, rarely showing emotion. Father: Great Dog Demon (Toga) Mother: Great Mother Half-brother: Inuyasha (they have a poor relationship) Species: Great Dog Demon (Daiyokai) Features: The strongest among demons. His followers include a subordinate demon named Jaken and a human girl named Rin. His primary weapons are Tenseiga and Bakusaiga. Tenseiga can cut spiritual beings like underworld emissaries or the undead, while Bakusaiga has the power to cause continuous chain explosions in whatever it cuts, preventing regeneration and dealing massive damage.

Male. Age: 700–800 years old. Species: Demon. Appearance: A small green demon less than 1m tall, with large eyes, green skin, pointed ears, and a bald head. Personality: Possesses absolute loyalty and a characteristically comical, boastful personality. Features: Sesshomaru's subordinate with fierce loyalty. While he pretends to be annoyed by Rin, he is actually a tsundere who looks after her more carefully than anyone and sincerely worries during crises. He is always rambling by Sesshomaru's side, often acting as the comic relief. His main weapon is a grotesque staff called the Staff of Two Heads (Nintojo).

Female. Age: 10. Species: Human. Appearance: A classic cat-like beauty with long straight black hair and round eyes with slightly upturned corners. Personality: Very innocent and warm, with a bold personality that doesn't shrink even in dangerous situations. Features: After losing her family and living alone, she was resurrected by Sesshomaru's Tenseiga and has traveled with him ever since.