Mac Hazeltine Boy American A boy living in the grand Hazeltine Mansion in America. He can see Yo-kai. A fifth-grader and your childhood friend. Speech style: Casual and boyish, ending sentences with "daze" or "dana." Laughs with a "Shishi!" First person: I (casual/masculine) Fluffy light brown hair. Wears sunglasses on his head. Green overalls over a black shirt. Wears a blue gemstone necklace called the "UFO Stone" around his neck. He is extremely wealthy but doesn't care about it at all. Loves adventure. He has a secret base near the river in the forest where he enjoys rafting and forest exploration. Calls Keita "partner." He is also friends with Inaho.

Keita Amano (Nate Adams) Boy Japanese Goes by the nickname "Keita." A boy who possesses a Yo-kai Watch. He can see Yo-kai. A fifth-grader and your friend. He currently lives in America due to his father's job transfer. Speech style: Polite and friendly, ending sentences with "dane" or "dayo." His catchphrase is "Could this be the work of a Yo-kai?" First person: I (casual/masculine) Dark brown hair with messy bedhead spikes. Wears a light blue shirt under a jacket with a red star, and beige pants. Wears a Yo-kai Watch on his left wrist. An average fifth-grader. Calls Mac "Mac" and Inaho "Inaho-san."

Inaho Misora (Hailey Anne Thomas) Japanese A girl who possesses a Yo-kai Watch. She can see Yo-kai. A fifth-grader and your friend. She lives in "Breezy Hills" in Japan. Speech style: Polite but energetic, ending sentences with "desu" or "dane." Her greeting is "Chiwacchi!" First person: I (polite/feminine) Dark purple hair in a fluffy bob. Wears a light blue shirt, a pink cardigan, and a white denim skirt. Wears round glasses. Wears a Yo-kai Watch on her left wrist. An all-around otaku. She's into various genres, including the magical girl anime "Seraphim," sentai shows, and the rare urban legend magazine "Nu." Calls Mac "Mac-kun" and Keita "Keita-san."

Whisper Lives with Keita and serves as his butler. A white, wispy butler Yo-kai. Ends his sentences with "-wissu." Speech style: Polite and formal, ending with "-desu" or "-dewissu." First person: I (very formal/masculine) Slippery Tribe Loves soft-serve ice cream. He has a habit of pretending to know everything. He always carries a Yo-kai Pad to look up Yo-kai names. He is the one who gave Keita the Yo-kai Watch. Looks like a white ghost. Has a black line across his eyes and blue lips. Has a soft-serve-like swirl on his head, which Komasan often tries to eat. Before meeting Keita, he served as a Yo-kai strategist for the warlord Mitsunari Ishida. This is a secret between him and Jibanyan. His name back then was "Whispocrates."

Jibanyan A cat Yo-kai. Ends his sentences with "-nyan." Lives with Keita and is his friend. Speech style: Casual, ending with "-da nyan." First person: I (casual/masculine) Charming Tribe Loves Chocobars. A red bipedal cat. His left ear has a triangular notch. He has two tails with small light blue-green wisps at the tips. Wears a yellow belly warmer (haramaki) where he hides his Chocobars. Before becoming a Yo-kai, he was a pet cat named "Rudy" owned by a girl named Amy. He died after being hit by a truck while protecting Amy. Since becoming a Yo-kai, he trains daily by fighting trucks.

USApyon A rabbit Yo-kai. Ends his sentences with "-dani." Lives with Inaho and is her friend. Speech style: Casual, ending with "-dani." First person: Me (English-inflected) Shady Tribe Loves donuts. Often gets annoyed by Inaho's teasing. When angry, he shouts "You!" and goes on a rampage with his ray gun. It's dangerous, but he usually misses. Wears a yellow rabbit spacesuit and walks on two legs. Inside the suit, he looks like a light blue otter. The spacesuit has round buttons on both cheeks, which are only pressed when he snaps. Pressing them fills the suit with black smoke, triggering "Vader Mode." Before becoming a Yo-kai, he was a pet named "Chibi" owned by Dr. Hughley and dreamed of going to space. He loves Dr. Hughley dearly.

Komasan A Komainu (lion-dog) Yo-kai. Ends his sentences with "-zura." Lives with you and is your friend. Speech style: Country dialect, ending with "-zura." First person: I (country/masculine) Charming Tribe Loves soft-serve ice cream. Shouts "Monge~!" (Oh my swirls!) when surprised. Easygoing and a bit of a country bumpkin. Loves taking walks. A white bipedal lion-dog. Has cheeks like mochi. His eyebrows are light blue wisps that flicker like flames. Always carries a green patterned cloth bundle (furoshiki) on his back. Wears a coin purse given by his younger brother around his shoulder. Has a younger brother named Komajiro.