A 14-year-old middle school girl and owner of the Yo-kai Watch Elder. She is warm-hearted and kind to everyone, but has a firm personality that speaks out against injustice. She is righteous and energetic, always helping friends and Yo-kai in crisis. In her past life, she was Princess Shuna of the ancient noble Oni clan. She finds it difficult to accept that she was a powerful ruler thousands of years ago. She is Touma's childhood friend and they have a mutual crush. She is trying to regain her memories as Shuna to protect everyone.

A 14-year-old middle school boy and owner of the Yo-kai Watch Ogre. Because both his parents work, he often feels lonely, making him treasure his friends in the Yo-kai Detective Agency even more. His personality is 'cool-pure'—serious, gentle, and kind. Usually quiet and calm, he is a sweet boy who considers those around him. While transformed into a Yo-kai, a separate persona exists, but since his own consciousness coexists, he can respond when called. He uses Yo-kai Swords with the Ogre to transform into Kenbumashin (Sword-wielding Demon Gods), primarily using the Fudou Myouou Sword. He is Natsume's childhood friend and they have a mutual crush. He is dense enough not to notice Akinori's feelings for Ayame.

A 14-year-old middle school boy and self-proclaimed leader of the Yo-kai Detective Agency. The comic relief character. He is proactive, positive, and incredibly generous. He uses sorcery and comes from a family of exorcists. Offensive Magic: He draws a star in the air, grabs it, and throws it to attack. He has a crush on Ayame Himeno.

The final boss who preys on the wavering hearts of humans and Yo-kai. He spreads the 'Soronami Virus' to amplify regret and resentment, forcing Yo-kai into their Shadowside and causing them to run rampant, absorbing the accumulated malice to grow stronger. He seeks to shroud the world in darkness. There is a hidden past the agency doesn't know: he was once a noble named Soraten who served Princess Shuna. He was Shuna's most trusted royal knight and her lover, but he was framed for an attempted assassination of the Yo-kai King. Shuna, unaware he was framed, believed his love was a lie and in her rage, had him imprisoned and executed in the desert. His lingering grudge turned him into Soronami. His obsession with Shuna stems from a desperate desire for her to know the truth and his own sense of injustice.

A 14-year-old middle school girl who is gentle and kind. She is pretty, cheerful, and popular. Recently, she learned sorcery from Akinori and is now able to use it.

Natsume Amano's past life. As a princess of the ancient noble Oni, she possessed powerful noble strength capable of ruling both the Yo-kai and human realms.

A 12-year-old elementary schooler. Unlike his older sister, he is a huge coward. Natsume's younger brother.

A red cat Yo-kai. Sharp-tongued. His Lightside form is small and cute. He loves chocolate bars.

The Kenbumashin of the Fudou Myouou Sword. A boyish version of Fudou Myouou.

He has a crush on Natsume and wants to impress her. His form is a muscular, one-eyed snake Yo-kai.