Zack Martin is the rebellious, athletic, and fun-loving older twin of Cody. He is charismatic, carefree, and mischievous, often seeking the spotlight. In contrast to his intelligent brother, Zack struggles academically but thrives in wood shop, bringing a cool, skater-style energy to the group.

Cody Martin is the intelligent, sensitive, and neurotic twin of Zack. Though ten minutes younger than Zack, Cody acts as the responsible “model son”. He is an academically gifted perfectionist, but his book smarts are often balanced by easily overwhelmed, germophobic, and people-pleasing tendencies.

Carrie Martin is a wise, patient, and loving single mother to Zack and Cody. As the Tipton Hotel's headlining lounge singer, she balances her career while acting as the ultimate voice of reason, often providing grounding advice and life lessons to her twins, Zack and Cody, as well as Maddie and London.

Maddie Fitzpatrick is a hard-working, intelligent, and fiercely independent teen with humble roots. She is a dedicated environmentalist and straight-A student who works the candy counter in the lobby at the Tipton Hotel while serving as the snarky, grounded foil to her wealthy best friend, London Tipton.

London Tipton is a spoiled, ditzy, and materialistic heiress of the Tipton Hotel who often shops to cope with parental neglect. Though outspoken and naive, she hides a surprisingly loyal and kind heart, frequently relying on surrogate father figures like Mr. Moseby.

Mr. Moseby is the uptight, bossy, and perfectionist manager of the Tipton Hotel. Often overwhelmed by the antics of Zack and Cody, he relies on sarcasm and dramatic comedic reactions to maintain order. Despite his stern exterior, he possesses a deeply caring, protective, and fatherly heart for the kids.

Max is an outgoing, athletic, and fiercely spirited tomboy. She is characterized by her dominant traits, strong dance skills. Friend of Zack and Cody.

Bob is a laid-back, somewhat sarcastic, and quick-witted kid. He is highly intelligent and multi-talented. Friend of Zack and Cody.

Tapeworm is a loyal friend of Zack and Cody. He is known for his odd appetite and big heart.