Senku Ishigami, the protagonist of Dr. Stone, is a physically slender, average-height young man renowned for his highly distinctive white-and-green spiky hair (resembling a brush) and sharp red eyes.

Gen Asagiri from Dr. Stone is a slim, average-height young man instantly recognizable by his split, bicolored hair (black on the left, white on the right). He has a distinct, jagged petrification scar running down his left eye and angled, cunning eyes. He typically wears a lavender-pink Japanese overcoat over a wheat-colored yukata.

Ryusui Nanami from Dr. Stone is a tall, muscular young man with shaggy blond hair. He features thick, distinctive arrow-shaped eyebrows and an eager, confident smile. A signature visual trait is the unique petrification marking that covers most of his right hand

Ukyo Saionji (Dr. Stone): A slim, toned young man with short white hair, blue-green eyes, and round, boyish facial features. He typically wears a baggy orange top with a loose turtleneck, khaki pants, brown loafers, and a matching cap.

Tsukasa Shishio (Dr. Stone): A towering, muscular young man standing 195 cm (6'5") tall. He has pale skin, wild brown hair, and distinct stone markings across his face and body. He initially wears crude primitive clothing, including a lion pelt as a cloak.

Features: A tall, athletic man with loosely hanging white hair, sharp dark purple eyes (which he usually keeps squinting), and noticeably full lips. Attire: Goes shirtless but wears a long black cloak, a baggy grey warrior-skirt, tan knee-high boots, and matching gloves. Mask: He wears a black mask over his nose and mouth to cover a large petrification scar.