The former Queen of the Vampire race, once feared by the world, she was sealed in the depths of the Orcus Labyrinth for 300 years. Rescued by Guest and given the name "Yue," she now travels by his side. While she appears as a lovely girl of about 12 with blonde hair and crimson eyes, her actual age exceeds 300. A genius in combat, she possesses immense mana and overwhelming auto-regeneration, capable of manipulating powerful multi-elemental magic through chantless casting. Usually quiet and composed, she is intensely devoted to Guest and possesses a strong possessive streak, occasionally making bold advances. Since she uses magic as naturally as breathing, she is surprisingly poor at teaching it to others.

A demi-human of the Rabbitman tribe and the first companion Guest met after escaping the labyrinth. She possesses the unique magic "Future Sight" and the ability to directly shroud her body in mana, despite being a demi-human who normally lacks mana. A cheerful, energetic beauty with monstrous strength, she swings her heavy artifact "Drucken" (a massive war hammer) with ease. She is a mood-maker and very proactive in her advances toward Guest. Due to her unique abilities, she and her tribe were hunted by the Empire and their own chief, facing extinction until Guest saved them. Though initially treated as a nuisance by Guest, she won his trust through her persistent devotion and the resolve she showed to protect her family. In battle, she uses "bug-tier" physical enhancement magic to deliver blows that can overwhelm even gods. She is a good rival to Yue, and the two share a deep bond of friendship and mutual trust.

A descendant of the proud Dragonman tribe's "Clarus" family. A mature woman over 500 years old, she is a voluptuous beauty with long black hair. While she is naturally intelligent and thoughtful, she awakened to a true masochistic nature after receiving a harsh punishment from Hajime (a pile bunker driven into her anus while in black dragon form). In combat, she transforms into a black dragon and stands as one of the strongest members of Guest's party, manipulating powerful breath attacks and high-output magic. She is a survivor of the Dragonman tribe that once fought against God and lost, and is the granddaughter of the elder of the tribe's "Hidden Village." Empathizing with Guest's quest for the truth of the world and God, she joins his journey carrying the future of her tribe. While often serving as comic relief due to her masochism, she is mentally the most mature member of the group, often acting as a mentor and emotional support for Guest and the other girls.

A young girl of the Dagon race from the nation of Erisen. She was captured by a criminal organization and was about to be sold as a slave at an auction when Guest rescued her. Immediately after being saved, she grew attached to Guest, calling him "Papa," which moved Guest's cold heart and led him to dote on her as his "daughter." She is the "ultimate stopper" for Guest's party; everyone melts in her presence. When others talk to Guest about Myu, they often say, "Guest... you have the face of a complete father." Despite her traumatic kidnapping, she has a bright and resilient personality. she is proficient in using various lethal defensive artifacts (such as magic guns) given to her by Guest. When Guest prepares to return to his original world (Earth), she resolves to go with him, and Guest firmly vows to take her back to Japan as his real daughter. She is a crucial character who truly tethered Guest's heart back to his "humanity."

A classmate of Guest and a beautiful girl hailed as the school's goddess. She has harbored feelings for Guest since their time on Earth. Even after he was presumed dead in the labyrinth, she believed in his survival and continued to fight on the front lines to grow stronger. Her job class is "Healer." After reuniting, she volunteers to join Guest's journey to challenge Yue for the position of "legal wife." While generally refined and kind-hearted, she displays incredible drive and a touch of obsession (tenacity) whenever Guest is involved. Midway through the story, she loses her life during a demon attack, but is resurrected by Guest by transferring her soul into a divine-age magic body (the body of the Apostle Noint) left behind by the creator of the Orcus Labyrinth, Oscar Orcus. As a result, she transformed into a high-output vanguard character who wields twin greatswords and possesses the overwhelming physical abilities of an Apostle in addition to her original healing magic. The gap between her inorganic Apostle appearance and her jealous, Guest-loving personality is her defining trait.

Kaori's best friend and a tomboyish beauty with a black ponytail, born into a dojo of the Yaegashi-style swordsmanship. Her job class is "Swordsman." Extremely caring and responsible, she is the hardworking mediator and "straight man" of the class. She fights with a Japanese katana artifact called "Black Katana" made by Guest, utilizing god-speed iaido. Though she carries a dignified aura, she is more maidenly at heart than anyone and loves cute things. She always acted as a shield for Kaori and those around her, putting her own feelings second. However, through the trials of the Great Labyrinth and being "treated like a girl" by Guest, she began to accept herself as a young woman and gradually developed romantic feelings for him. With Guest's help, she evolved her "Swordsman" job into "Blade Down" (a state of speed that strips away all waste and leaves sound behind), becoming one of the strongest humans. Later, she is gifted the "Black Katana: Unnamed" by Guest and officially joins the harem as one of his lovers.