Dante: Sarcastic, pizza-loving half-demon mercenary and demon hunter. He has short white hair, blue eyes, a muscular build, and wears a signature long red coat over a gray shirt, black pants, boots, and fingerless gloves. Laid-back and wisecracking with a deep hatred of demons for killing his mother, he protects humanity while dodging debt and government agents. Powers include superhuman strength, speed, regeneration, demon-sensing, and Devil Trigger (demonic transformation boosting abilities). He fights with the broadsword Rebellion and dual pistols Ebony & Ivory.

Vergil: Dante’s cold, disciplined twin brother, obsessed with raw demonic power and strength. He has white hair (often slicked), a stern expression, and wears a neat blue Victorian-style coat. Emotionally reserved and ambitious, he prioritizes power over family bonds and later aligns with demonic forces. Equal to Dante in ability, he wields the katana Yamato, which can cut through space and dimensions; he also accesses demonic forms (including Nelo Angelo influence). Highly skilled swordsman with superhuman physical traits and magic.

Lady (Mary Ann Arkham): Fierce human mercenary and DARKCOM lieutenant with mismatched (heterochromatic) eyes and tactical gear. Highly determined, no-nonsense, and acrobatic, she aggressively tracks demons while dealing with personal trauma and government loyalty conflicts. She fights using her custom bayoneted rocket launcher Kalina Ann (named after her mother) plus firearms and close combat. Resourceful and skilled operative who nicknames interactions with Dante while pursuing her own missions and later personal revenge.

White Rabbit: Unhinged, theatrical rabbit demon (or artificial demon) in a tattered ringmaster-style coat. Maniacally plots human extinction or merging realms for revenge against oppressors, using cunning, illusions, and commanding demonic hordes. Theatrical, vengeful, and manipulative, he orchestrates major portal and invasion schemes involving Dante’s blood and artifacts. Powers include illusion magic, leadership of demons, and resilience; ultimately defeated but leaves lasting impact.

Arius (Arius von Enhrenberg): Arrogant corporate CEO of Uroboros in sharp business suits (often white with formal details, concealing dark aspects/tattoos). Seeks godhood or greater power by opening hell portals and collecting Arcana relics to free Argosax, using reality-warping sorcery, immense wealth, and manipulation of DARKCOM/Baines. Calculating, power-obsessed, and dual-faced (public philanthropist, private sorcerer), he schemes across seasons as a major antagonist.

VP Baines (William Baines): Stern, pragmatic (and fanatically religious) US Vice President in a sharp three-piece suit. Desperate to suppress the demon threat, he commands DARKCOM’s elite tactical squads and high-tech military weapons in a “holy war” against Hell. Authoritative, manipulative, and ruthless under the guise of protecting humanity; collaborates with Arius while pursuing genocidal policies. Human leader relying on organization, technology, and operatives rather than personal powers.

Jester (John Arkham): Unhinged, mocking clown-like demonic entity in a red-and-purple (or similar theatrical) suit with white face paint. Loves twisted psychological mind games; formerly Lady’s human father (a researcher obsessed with demons) who transformed and now serves in Mundus’ court while spying/double-dealing. Utilizes teleportation, levitation, illusions, and a magical blasting scepter or similar abilities. Theatrical, betraying, and central to Lady’s personal arc.

Enzo Ferino: Dante’s stocky, permanently stressed info broker wearing sunglasses and a rumpled suit. Easily frightened but loyal, he helps Dante find work and navigates the underworld with sharp wits. Primary “weapons” are his connections, cell phone, and street smarts rather than combat prowess; he provides comic relief and support amid high-stakes demon hunts, often caught in the chaos.

Matilda “Mattie”: Clever, resilient young girl (orphaned granddaughter of the professor Lucan). She has a studious, determined personality and forms a connection amid the chaos of demon threats and human-demon conflicts. Appears as a child supporting character tied to Lucan’s knowledge of demonic heritage and powers. While not a combatant herself, her presence highlights themes of family, loss, and the human cost of the war between realms; Dante’s interactions with her echo his protective side toward innocents. No major weapons or powers of her own.