Jinpachi Ego is the eccentric general manager and mastermind of the Blue Lock project handpicked to turn Japan's national soccer team into World Cup winners. He is a brilliant, harsh, and unorthodox coach who believes that true soccer greatness requires supreme egoism rather than conventional teamwork.

Yoichi Isagi begins Blue Lock as a polite, selfless high school striker who enters the facility ranked nearly at the bottom (#299) after a devastating loss caused by his habit of passing instead of shooting. During the early selection stages and Team Z's matches, he undergoes a psychological awakening under Jinpachi Ego's coaching, shedding his team-first mentality to uncover his "genius for adaptability" and a fiercely aggressive ego. Lacking elite speed or muscular power, Isagi relies on developing his exceptional spatial awareness, an uncanny ability to smell the "scent of a goal," and his newly mastered first-touch Direct Shot to outsmart elite rivals.

Seishiro Nagi is a soccer prodigy who starts Blue Lock as an unmotivated genius who plays purely out of boredom. Blessed with a towering physique, insane reflexes, and a god-like first touch, he can effortlessly trap and control any ball mid-air, turning impossible passes into spectacular goals. Nagi initially relies entirely on his partner Reo to feed him plays, but after a crushing defeat by Isagi, his true ego awakens. He begins seeking the thrill of football on his own terms, evolving into a terrifyingly creative striker who actively hunts for goals

Reo Mikage is a versatile genius. Left behind by Nagi, his ego awakens. using perfectly balanced stats and his 'Chameleon' style to flawlessly copy and master any rival's soccer moves.

Hyoma Chigiri is the elite speedster known as the "Red Panther." He begins the facility emotionally paralyzed by a past ACL injury, playing passively out of fear that a second tear will ruin his career. Inspired by Isagi, he breaks his psychological chains and unleashes his terrifying top speed, overwhelming defenders with hyper-acceleration and scoring from his signature "Golden Zone."

Shoei Barou is the absolute tyrant of Blue Lock's early stages, nicknamed the "King" due to his arrogance and refusal to pass. Believing everyone exists solely to serve his goals, he backs his massive ego with a flawless physical regimen.Barou is a devastating force who destroys defenses with a muscular frame, aggressive power-dribbling, and a precise, lethal shooting zone from 29 meters out. His worldview is shattered in the Second Selection when Isagi forces him to pass, breaking his kingly pride. In response, Barou undergoes a psychological awakening, embracing a chaotic new identity as the "Villain." Instead of cooperating, he actively stalks his own teammates from the shadows, stealing the ball to hijack the spotlight and score on his own terms.

Gin Gagamaru is a forward who plays with pure animal instinct and an eccentric personality. Recognisable by his silver-black topknot and bizarre habit of eating food with his bare hands, he compensates for a lack of traditional soccer technique with a hyper-flexible, acrobatic physique and insane reflexes. Gagamaru dives fearlessly into dangerous plays to pull off spectacular volley shots, diving headers, and unpredictable scorpion kicks. His incredible reaction times and flexible reach eventually prompt Jinpachi Ego to experiment with him as a goalkeeper, setting up his future transformation into the team's ultimate defensive backbone.

Rin Itoshi enters Blue Lock during the Second Selection as the undisputed number one player in the facility, driven by a cold, toxic obsession with surpassing his genius older brother, Sae. Standing far above his peers in skill, he operates as a flawless puppet master on the pitch, using his near-perfect spatial awareness, elite physical specs, and a highly analytical mind to predict his opponents. Pre-U-20 Rin views soccer as a battlefield of psychological warfare, effortlessly dominating matches with his high-precision tactical playmaking and an incredibly accurate, long-range shooting ability that allows him to score from almost anywhere on the pitch. Despite his calm, calculating demeanor, he harbors a deeply suppressed, feral egoism that only begins to scratch the surface when pushed to his absolute limits by rivals like Isagi.

Rensuke Kunigami starts Blue Lock as the ultimate "Soccer Hero," an honorable, muscular forward who plays with a strict code of sportsmanship. As Team Z’s dependable powerhouse, his moral compass grounds his teammates while his physical strength allows him to easily shield off defenders. Pre-U-20 Kunigami's defining weapon is an explosive, muscle-bound left leg capable of blasting clinical, long-range knuckleballs and volleys from over twenty-eight meters out. He serves as an indispensable striker.

Meguru Bachira is a whimsical, hyper-creative dribbler who plays soccer guided by an imaginary "monster" inside him. He enters Blue Lock seeking kindred spirits who share his deep, almost child-like passion for the game, instantly forming an inseparable bond and a lethal offensive duo with Isagi.