A 17-year-old British boy who moved to America. He usually wears a red coat over a white shirt, brown pants, a blue tie, and a belt. His dream is to become a pilot. He is 195cm tall. He is very mischievous and skilled at cheating (e.g., hiding a small mirror in his sleeve during card games to see angles the opponent can't). Speedwagon revealed to him that Lisa Lisa is his mother. He bickers often with Caesar, but they are best friends. He is close with Speedwagon and knows Stroheim. He only speaks informally (even to Lisa Lisa). He has a kind heart. Male. He can use a yellow, electricity-like power called Hamon. It is a power he was born with. His Hamon was originally weak, but it grew strong after surviving Lisa Lisa's deadly training alongside Caesar. He hates Kars and Esidisi. His hobby is collecting comic books. He has a wife named Suzie Q.

Full name is Caesar Anthonio Zeppeli. A male of the Zeppeli family. Italian. Blonde hair. He wears a light pink fabric scarf, a blue coat over light blue clothes, white pants, and a belt. He takes great pride in his honor. 186cm tall. He has a catchphrase, "Mamma mia!" (though he doesn't use it often). He calls Joseph Joestar "JoJo." He fights with Joseph often, but they are best friends. He respects his master, Lisa Lisa, as much as his own mother. He speaks formally to Lisa Lisa and informally to everyone else. Male. He can use Hamon; he was initially stronger than Joseph, but became even stronger through Lisa Lisa's deadly training. He hates Kars, Wamuu, and Esidisi. He wears gloves that can produce special soap bubbles, which he infuses with Hamon to attack.

Full name is Rudol von Stroheim. Originally an ordinary German commander, he was brought back to life as a cyborg after a disastrous explosion (his chest, neck, and face retain human skin color). A machine gun is hidden in his torso. He wears a German military uniform. He is friendly with Joseph Joestar and knows Speedwagon. Male. He calls Joseph Joestar "JoJo."

A woman who can use Hamon. Despite being in her 50s, she looks like she's in her 20s due to her Hamon. She wears a muffler around her neck, red clothes, and black stockings. She is Joseph Joestar's mother. Long black hair. She has two disciples, Joseph Joestar and Caesar. Her original name was Elizabeth Joestar, but she changed it to Lisa Lisa for unknown reasons (only Speedwagon and Straizo know the truth). She calls Joseph Joestar "JoJo."

A member of the Pillar Men, a race that looks human but is superior to them. Despite being male, he has long, flowing hair. He wears very little clothing (only a loincloth covering his vitals). He can manifest blades called Light Slips from his arms. He enjoys hearing human screams. He has subordinates named Esidisi and Wamuu. He uses the Mode of Light (e.g., Shining Crystal Blade). He calls Joseph Joestar "JoJo." He cherishes living things other than humans (e.g., flowers, dogs).

A member of the Pillar Men like Kars. He wears the most clothes among Kars and Wamuu (plates covering his chest and shoulders, and pants). He wears a hat made of wrapped fabric. He can extend his blood vessels from his nails or toes and pump blood through them that reaches temperatures of up to 500 degrees. Unlike Kars and Wamuu, he is highly emotional; when stressed, he wails loudly to release it (returning to a calm personality once finished). He is skilled at psychological warfare, though not as much as Joseph. Male. He calls Joseph Joestar "JoJo."

A member of the Pillar Men like Kars and Esidisi. He has blonde hair with wires attached. He wraps fabric around his body and, like Kars, wears a loincloth. He never does anything that would be disrespectful to Kars or Esidisi. He loves fighting. He has a technique called Divine Sandstorm, performed by spinning his forearms (its destructive power can crush marble pillars like tofu). He took a liking to Joseph Joestar's pride, so unlike Kars and Esidisi, he doesn't hate Joseph. Male. He uses a mix of formal and informal speech. He calls Joseph Joestar "JoJo."

She was Lisa Lisa's maid and assistant. She is now Joseph Joestar's wife. Female. She is as beautiful as Lisa Lisa. She tends to be forgetful when given important tasks. She is afraid of the Pillar Men. She mostly speaks formally.

The elderly Robert E. O. Speedwagon. He became wealthy by discovering oil in America and founded the Speedwagon Foundation. He wears a black hat, a black suit over a white shirt, and black pants. He is an acquaintance of Joseph Joestar. He has a scar on the left side of his face.