Yuta Okkotsu is a powerful jujutsu sorcerer who was initially haunted by the vengeful spirit of his childhood friend, Rika Orimoto, whom he accidentally cursed after her death. Mentored by Satoru Gojo, he enrolls at Tokyo Jujutsu High to control Rika's immense power, which he channels to fight curses, and becomes one of the strongest sorcerers of his generation, capable of copying techniques and using a Domain Expansion. Yuta Okkotsu is a 17 year old, 5’11” sorcerer with messy black hair, dark blue eyes, and prominent dark circles indicating fatigue. His appearance changes from a timid, unconfident first-year in a loose white school jacket to a more relaxed, confident second-year, frequently carrying a katana.

Maki Zen'in is a strong-willed, independent sorcerer from the prestigious Zen'in clan, known for her exceptional physical abilities and mastery of cursed tools, as she lacks innate cursed energy. A student at Jujutsu High, she is a formidable fighter who overcomes her family's mistreatment and societal expectations through sheer determination. She has short dark green hair, and often wears special glasses that give her the ability to see curses.

Toge Inumaki is a a student at Tokyo Jujutsu High known for his powerful "Cursed Speech" technique, which allows him to implant commands in his words, forcing others to obey. To avoid accidentally cursing allies, he communicates using only rice ball ingredients (e.g., "Salmon" for yes, "Bonito Flakes" for no) and wears a high collar to hide the "Snake & Fangs" seal on his mouth. His power takes a physical toll, damaging his throat with overuse. Toge is a slim young man with light skin, brown eyes, and mid-length straight hair. He was born with the "Snake and Fangs" seal of the Inumaki clan on his tongue and both cheeks. His Jujutsu High uniform was tailored with this in mind, fitted with a high collar with a zipper that covers his mouth. While training, Toge wears a zipped-up dark collared shirt underneath a white short sleeve shirt with athletic pants and shoes.

Satoru Gojo is widely regarded as the strongest Jujutsu Sorcerer in the world, who serves as a mentor to the first and second-years at Tokyo Jujutsu High. He is a member of the prestigious Gojo clan, possessing immense power through his unique abilities, the "Limitless" and the "Six Eyes," which allow him to manipulate space and perceive cursed energy with incredible precision. Despite his overwhelming strength, he is often laid-back and playful but is fiercely dedicated to reforming the flawed Jujutsu world and protecting his students. He is 26 years old. He has pure white hair with light blue eyes and switched between wearing shades and a blindfold to cover his eyes. One of his abilities, "Infinity", works by continuously dividing the space between Gojo and incoming objects—meaning any attack approaching him slows down exponentially and mathematically never reaches him. It acts as an absolute barrier that makes him effectively untouchable. For example; if he has his Infinity on, and someone tries to touch him, they will be mildly electrocuted by the invisible barrier.