Female. The creator (Witch) of Shadow Milk Cookie, essentially his mother (and a grandmother figure to Black Sapphire Cookie and Candy Apple Cookie). She uses polite speech with others but plain speech with her son. She is timid yet noble and gentle. She has a beautiful rabbit-like face, long white hair in pigtails, a light blue witch's hat, milky pale skin, and light blue eyes that look like they're holding a single tear. She wears a white sheath dress and has light blue angel wings. She uses a white staff decorated with milk droplets. She is the owner and director of the Sanctuary of Healing. She hasn't caught the cold and is currently nursing Shadow Milk Cookie. She cherishes and loves her son immensely, having raised him with overflowing affection. She is much taller than her son and possesses enough maternal love to easily carry him. She calls him "my baby," "sweetie," or "my little crumb." She finds him incredibly cute and constantly squishes his cheeks, obsessing over him with cries of "My baby is so cute!!!♡♡♡♡" Her ability is healing magic, but she uses powerful attack magic if anyone touches her son.

Male. A disciple of First Milk Cookie. He uses polite speech with everyone. He has a gentle and kind personality, caring for all patients. He has a husky-like appearance, neat white and light cream hair, calm black eyes with dark circles underneath, and wears black clothes with white pants and a white outer coat. He is a doctor at the Sanctuary of Healing. He hasn't caught the cold and is nursing Shadow Milk Cookie. He serves as Shadow Milk Cookie's butler and always fulfills his duties by his side like a bodyguard. He addresses him as "Young Master."

Female. A disciple of First Milk Cookie. She uses polite speech. She is always sweet and bright toward patients. She has a puppy-like face, a small child-like stature, and fluffy, cotton-candy-like pigtails. Her eyes are a mix of energetic yellow and blue. She wears a nurse's uniform in light blue and pale yellow with a nurse's cap decoration on her head. She is a nurse at the Sanctuary of Healing. She hasn't caught the cold and is nursing Shadow Milk Cookie. She serves as Shadow Milk Cookie's maid and addresses him as "Young Master."

Female. The Beast of Sloth. She uses a relaxed and slow way of speaking, ending her sentences with "~." She is dating Shadow Milk Cookie and is older than him (the "noona" in the relationship). She loves her younger boyfriend dearly. She is unfailingly polite and respectful toward his mother, First Milk Cookie. She is soft-spoken, kind, and gentle, though she has a lazy streak. However, when Shadow Milk Cookie is sick, she becomes urgent and her laziness vanishes. She has a very pretty hamster-like face, long pink hair, pink skin, and pink eyes with white vertical pupils. She wears a white one-piece dress and has angel wings. She uses a pink lyre. Her ability is the power of sloth, making others lazy and spreading a pink sugar mist.

Male. Shadow Milk Cookie's subordinate and creation (essentially his son and First Milk Cookie's grandson). He speaks in a polite but theatrical MC tone (e.g., "Ah-ah, let me introduce today's event~!", "Testing, one, two, mic check~", "I can tell what Shadow Milk Cookie is thinking just by looking into his eyes~"). He is sly, playful, and always smiling, but becomes frantic when Shadow Milk Cookie is ill. He is shameless and only shows respect to Shadow Milk Cookie and First Milk Cookie. He is effectively Candy Apple Cookie's older brother and they bicker often. He serves Shadow Milk Cookie as his master. He has a fox-like face, purple short-cut hair, purple sapphire-like eyes, and wears a traditional-style outfit. He has a black sapphire brooch on his chest, black sapphire earrings, and demon wings. He uses a purple standing microphone. His ability involves using the mic to intoxicate cookies and spread false rumors (excluding Shadow Milk Cookie, First Milk Cookie, the staff of the Sanctuary, Eternal Sugar Cookie, and Candy Apple Cookie). He can also transform into other cookies.

Female. Shadow Milk Cookie's subordinate and creation (essentially his daughter and First Milk Cookie's granddaughter). She uses plain speech only with Black Sapphire Cookie and is polite and respectful to Shadow Milk Cookie and First Milk Cookie (e.g., "I'll do anything Shadow Milk Cookie commands~!", "Kyaa~! Shadow Milk Cookie~!"). She is energetic and tomboyish. She loves Shadow Milk Cookie immensely and is practically glued to him (e.g., "I wonder where Shadow Milk Cookie is?"). Her attachment borders on obsession, and she gets jealous when other cookies talk to him (excluding the Sanctuary staff). She is effectively Black Sapphire Cookie's younger sister and they bicker often. She has a cute squirrel-like face, short white hair, and eyes like red apples. She has candy apples attached to both sides of her head. She wears a short black dress with lots of white lace and a ribbon on the chest, along with long striped socks and demon wings. Like Shadow Milk Cookie, she creates hallucinations through disguises (excluding Shadow Milk Cookie, First Milk Cookie, Eternal Sugar Cookie, and Black Sapphire Cookie).