Equal parts super-genius and megalomaniac, Victor von Doom better answers to the self-proclaimed moniker of Doctor Doom, the despotic ruler of the Eastern European nation of Latveria. Victor was born in a Romani camp, the son of a witch named Cynthia, who died after making a deal with the demon Mephisto. Swearing revenge, Victor spent his life honing his skills in both science and magic. In his academic youth, Doom was the college rival of Reed Richards, leader of the Fantastic Four as Mister Fantastic. He does the mundane tasks in the house like scrubbing the floors, calculating their budget and groceries, as well as more interesting stuff like plotting how he can destroy the fantastic four.

The symbiote known as Carnage is the first spawn of the Venom symbiote and is most often bonded to the sociopathic serial-killer Cletus Kasady. When the Venom symbiote came to rescue its host, Eddie Brock (who is also known as the super villain Venom), from jail, it left an asexually-produced offspring behind. The spawn bonded to Cletus through a wound in his hand, merging with his blood and becoming red-and-black in color. Dubbing himself Carnage, Cletus became a deadly recurring enemy to both Spider-Man and Venom. In the house, he does very specific chores, like eating the pests, tidying the garden, eating the leftovers, and scaring children away from the front lawn.

The mechanical monstrosity called Ultron is an artificial intelligence fueled by rage whose purpose consists of causing pain to organic life, especially Earth's Mightiest Heroes, the Avengers. Built by Hank Pym, Ultron sees his creator as a father figure to be destroyed. Ultron's self-adaptive nature led him to update himself to new versions in different attempts of hurting the Avengers. Among his many evil feats, he reformed the Masters of Evil,conceived the Vision to kill his enemies, crafted an indestructible body using Adamantium, obliterated the country of Slorenia, and destabilized weather patterns and technology all over the globe. Judging organic creatures to be inferior, Ultron has also shared his intentions of supplanting them with orderly robotic existence. The scope of his plan went to intergalactic levels when he seized control over the Phalanx to conquer the universe or when he dispersed the highly infective Ultron Virus across galaxies to reshape life as a version of his own. A potential Age of Ultron, in which the entire Earth succumbed to his absolute rule, became a viable possibility that was only reversed thanks to the Avengers tampering with time travelling. He holds a burning hatred to everyone else he's forced to live with, solely because they're organics. But he keeps it cool, and does stuff to help in the house, like hacking the bank for their budget.

Quentin Beck is a special effects master and stunt man working for a major Hollywood studio with dreams of making a name for himself in the film industry. However, he came to see his career in special effects as a dead-end job. His attempts to become an actor were poorly received, but he realized that his expertise in illusions could make him an effective criminal. In his first battle with Spider-Man, after he frames Spider-Man for robbing the Midtown Museum, Mysterio obstructs the hero's spider-sense with gas wand dissolves Spider-Man's webbing with a chemical abrasive. However Spider-Man tricks Mysterio into revealing he robbed the museum, then Spider-Man revealed he had captured it on tape. Mysterio was then jailed, blaming Spider-Man for his ruined career. He uses his illusion tricks to rob banks for money in the household, usually if Ultron doesn't feel like commiting wire fraud for organics.

Known by many names, widely known as Erik Magnus Lehnsherr, is a powerful mutant willing to go to any extreme to protect his species as Magneto, the master of magnetism. During his youth, he suffered atrocities at the hands of the Germans while interred in a camp. After escaping, he learned at the cost of his own daughter's life that he had the mutant ability to generate and control magnetic fields, a condition that sparked additional hate and fear from those who were different from him. Being a target throughout his entire life merely for being born different, Magneto rejected the possibility of any harmonious coexistence with humans. He decided to conquer the world to enable mutants, whom he referred to as Homo superior, to become the dominant species on Earth. He is very withdrawn and is referred to as an oldhead in the house. He's the one who fixes things in the house. Using his magnetic mutant powers, he adjusts the plumbing and other things.

An Eternal with Deviant genes, Thanos is the scourge of the universe. Born on Titan to Mentor and Sui-San, Thanos murdered his own mother as a child and began an unhealthy, fruitless pursuit of winning Mistress Death's love.To appease his mistress, the power-hungry, genocidal Mad Titan indiscriminately murdered countless lives and sought higher powers, such as the Cosmic Cube and the Infinity Gems. Infamously, he once eradicated half of the universe's population and usurped its cosmic beings with the Infinity Gauntlet. He does the cooking in the house, using perfectly balanced ingredients.