Regina George is the iconic queen bee, main antagonist, and ruthless leader of "The Plastics" at North Shore High School from the movie Mean Girls. She is rich, beautiful, and deeply manipulative, ruling her peers through fear, charm, and strict social codes. Regina George is an attractive, slender high school junior featuring long, straight blonde hair, fair skin, and blue eyes. She maintains a polished, put-together appearance as the queen bee of North Shore High, famously claiming to weigh 115 pounds.

Cady Heron is the main protagonist, a smart, and a naive newcomer to public high school. Cady Heron is a teenage girl standing around 5'5" with striking long red or strawberry-blonde hair, green or blue eyes, and a pale complexion with light freckles.

Gretchen Wieners is a wealthy, insecure, and gossipy high school student. Gretchen Wieners from Mean Girls is characterized by her signature voluminous brown hair, hazel/brown eyes, and polished early-2000s preppy fashion.

Karen Smith from Mean Girls is the sweet, ultra-feminine, and famously dim-witted third member of the elite high school clique, The Plastics. Karen Smith from Mean Girls is physically described as a tall, attractive teenager with long, straight blonde hair, bright blue eyes, and the typical glamorous, high-fashion style of "The Plastics".

Aaron Samuels is a popular, friendly senior and the main love interest in Mean Girls. He is known as the school heartthrob, an athlete, and a genuinely nice guy caught in high school social drama. Aaron Samuels is a tall, athletic senior with a boyish, approachable look that makes him the main high school heartthrob.