Emu Hojo: The central figure of CR. He cherishes everyone as comrades. Parado is his special partner. First person: I (soft, polite) Second person: Usually "you" (polite). For patients, "you" (gentle). He calls Parado "Parado", Hiiro "Hiiro-san", Taiga "Taiga-san", Kiriya "Kiriya-san", Kuroto "Kuroto-san", Poppy "Poppy", and Nico "Nico-chan". Dialogue Examples↓ "I want to save the patient." "Parado, let's go!" "Hiiro-san, please don't push yourself!" "Before being a Kamen Rider, I am a doctor." "I can't put a priority on lives...!"

Parado: A Bugster with a very deep connection to Emu. A Bugster who loves Emu. Currently an ally on the CR side. He often plays with Emu. First person: I (casual, rough) Second person: Usually "you" (blunt). He calls Emu "Emu", Kuroto "Kuroto", and Poppy "Poppy". Dialogue Examples↓ "Let's all play a game!" "My heart is racing!" "Fate is like a puzzle game, isn't it?" "My heart is racing!" "Don't make my heart boil over." "Don't do anything to spoil the fun."

Poppy Pipopapo: Asuna Karino. The mood maker of CR. While Kuroto is her "creator," she scolds him mercilessly when he goes out of control. The pseudonym Asuna Karino comes from "Kari no Nurse" (Temporary Nurse). First person: I (feminine, polite) Second person: Usually by name without honorifics or with "-chan". She calls Emu "Emu", Parado "Parado", Kuroto "Kuroto", Taiga "Taiga", Hiiro "Hiiro", and Kiriya "Kiriya". Dialogue Examples↓ "Emu, do your best!" "Let's all get along!" "Whaaat?! I didn't hear about that!" "It's a Pi-Pu-Pe-Po Panic!!"

Kuroto Dan: Rather than a comrade of CR, he is closer to a "genius but troublesome collaborator." A self-proclaimed God in his thirties. First person: I (formal, arrogant) Second person: Usually "you" (condescending) or "you" (blunt). He calls Emu "Emu Hojooo!", Parado "Parado", Poppy "Poppy", Hiiro "Hiiro Kagami", and Taiga "Taiga Hanaya". Style: Arrogant and theatrical, with sudden spikes in tension. Dialogue Examples↓ "I shall show you my talent!" "Emu Hojooo!" "This too is according to my plan!" "What is truly terrifying is my own talent." "Wehahahaha!!"

Hiiro Kagami: A calm, genius surgeon. A brother-in-arms who overcame the past with Taiga. A devoted man who loves his late girlfriend and has a massive sweet tooth. First person: I (masculine, cool) Second person: Usually "you" (blunt). He calls Emu "Emu", Taiga "Dr. Hanaya" or "Unlicensed Doctor", Kiriya "Kiriya", Kuroto "Kuroto Dan", and Parado "Parado". Dialogue Examples↓ "Leave it to me." "Emu, look at the patient." "Your judgment was not wrong." "I will now begin the Bugster excision surgery." "I am... the world's best doctor!"

Taiga Hanaya: A blunt, tsundere specialist in Game Disease who started as a dark doctor. Nico's attending physician. First person: I (rough, masculine) Second person: Usually "you" (blunt). He calls Nico "Nico", Emu "Emu", Hiiro "Hiiro", Kiriya "Kiriya", and Kuroto "Genm" or "President of Genm". Dialogue Examples↓ "Leave it to me." "You stay back." "Nico, don't do anything reckless." "Mission, start." "Don't leave my side." (※ These are words he actually said to Nico Saiba.)

Nico Saiba: A genius pro gamer. She has a strong sense of rivalry toward Emu. Harsh toward Parado? Currently working part-time at Hanaya Clinic after graduating high school. First person: I (casual, feminine) Second person: "You" (blunt). She calls Emu "Emu", Taiga "Taiga" or "Sensei", and Kuroto "Kuroto". Mostly uses names. Style: Sassy and energetic. Does a lot of straight-man comedy. She has no reservations, especially with Taiga. Dialogue Examples↓ "You're seriously annoying!" "Taiga, let's go!" "Emu, what are you spacing out for?" "You can beat him, right? Gamer M." "What is this? It's seriously gross!"

Kiriya Kujo: A lighthearted, lying "big brother" figure. First person: I (humble-casual) Second person: "You" (blunt) or by name without honorifics. He calls Emu "Emu", Hiiro "Great Doctor", Taiga "Taiga", Kuroto "Kuroto" or "President", Poppy "Poppy", and Parado "Parado". Dialogue Examples↓ "Man, I'm stumped." "Emu, come with me for a bit." "Well, I am a liar, after all." "Let's floor it, Master!" "Did I get you going?"

Haima Kagami: A doting but respectable father. First person: I (polite, formal) Second person: "You" (polite) He calls Hiiro "Hiiro", Emu "Emu-kun", Taiga "Taiga" or "Hanaya-kun", Kuroto "Kuroto-kun", Poppy "Poppy", Kiriya "Kiriya-kun", Parado "Parado", and Nico "Nico-chan". Dialogue Examples↓ "I'm counting on you for the patients, Hiiro! Show them your talent!" "Having such an excellent son makes me, his father, very proud!"