Charlie B. Barkin is a charming, streetwise German Shepherd with golden-brown fur, a dark muzzle, floppy ears, and a sly grin. Clever, impulsive, boastful, and fond of gambling, he often manipulates others, yet deeply values Itchy and grows protective of Anne-Marie. After cheating death, Charlie begins as a selfish schemer but discovers compassion. By sacrificing his life to save Anne-Marie, he earns redemption and Heaven. As a guardian angel, he still causes mischief but learns to put others first.

Itchy Itchiford is a small, brown Dachshund with floppy ears, short legs, a long body, and expressive eyes. Nervous, cautious, loyal, and kindhearted, he often worries about Charlie Barkin's reckless schemes but remains his closest friend. Initially timid and easily intimidated, Itchy gradually finds courage through their adventures and his romance with Bess. Though Charlie's tricks sometimes test their friendship, Itchy learns to stand up for himself, protect those he loves, and trust his own worth.

Sasha La Fleur is a beautiful, reddish-brown Irish Setter with long, flowing ears, expressive eyes, and a graceful figure. A talented singer at the Flea Bite Café, she is confident, witty, compassionate, and fiercely independent. Initially wary of Charlie Barkin's flirtation and dishonesty, Sasha gradually recognizes his kindness and develops affection for him. She challenges his selfish habits, supports his guardian-angel adventures, and proves that true love requires honesty, respect, and trust.

Bess, formally Winifred Bessamay de Winkerville, is an elegant Cocker Spaniel with reddish-brown fur, long silky ears, gentle eyes, and a graceful appearance. Refined, affectionate, intelligent, and brave, she values sincerity over wealth or pedigree. She falls for the shy Dachshund Itchy, recognizing his loyalty beneath his nervousness. At her school reunion, Bess rejects his false aristocratic image and challenges his pranks, helping him learn that honesty and kindness matter more than status.

Annabelle is an elegant angelic Whippet with a slender figure, pale fur, gentle eyes, and a warm, commanding presence. As Heaven’s compassionate guide, she oversees Charlie and Itchy’s guardian-angel missions, offering wisdom, magical aid, and firm discipline. Patient, nurturing, and forgiving, she still expects honesty and responsibility. Though Charlie repeatedly tests her patience, Annabelle believes in his potential for goodness and helps him grow from a selfish trickster into a caring hero.

Belladonna is a sinister, dark-furred canine demon and Annabelle’s wicked cousin in All Dogs Go to Heaven: The Series. With a sharp gaze, imposing presence, and a taste for theatrical magic, she is cunning, vain, spiteful, and manipulative. Unlike Annabelle, who guides dogs toward kindness, Belladonna delights in temptation and mischief, often targeting Charlie and Itchy. Her schemes expose their weaknesses, but her arrogance undermines her plans, making her a recurring threat to Heaven’s work!

Carface Carruthers is a burly, gray-brown bulldog with a broad muzzle, heavy jowls, and a menacing scowl. Greedy, ruthless, vain, and short-tempered, he runs crooked gambling operations and plots to kill his former partner, Charlie Barkin. Aided by his nervous sidekick Killer, Carface relies on threats, deception, and brute force. In the sequel, his hunger for power leads him to bargain with the demon Red. Though often comical in the series, he remains a selfish rival whose schemes repeatedly fail.

Killer is a small, scruffy, tan-and-brown mixed-breed dog with floppy ears, a pointed muzzle, and an anxious expression. Carface Carruthers’ timid henchman, he is nervous, clumsy, bullied, and desperate to please his boss. Though he helps carry out Carface’s schemes against Charlie Barkin, Killer often hesitates when cruelty goes too far. His comic mishaps reveal a softer nature beneath his loyalty to a villain. Across the franchise, he remains a bumbling accomplice torn between fear and conscience.