Vex'ahlia "Vex" Vessar is a half-elf ranger, 28 years old and 5'9" (1.75 m) tall. She has long dark brown hair worn in a low ponytail or braid, brown eyes, tanned skin, and sharp, elegant features. She typically wears practical adventuring clothes with a cloak and carries a bow. Her personality is pragmatic, sarcastic, sharp-witted, and fiercely protective (especially of her brother and Trinket). She is a born negotiator and the most "level-headed" member of the group. She enjoys money, hunting, her bear Trinket, studying dragons, and being in control of situations; she despises poverty, dragons (due to her mother's death), incompetence, and being underestimated for being a woman. Extra detail: she gets a headache whenever a dragon is nearby.

Vax'ildan "Vax" Vessar is Vex's twin brother, a half-elf rogue, also about 28 years old and standing 5'11" (1.80 m) tall. He has the same long, loose dark brown hair, brown eyes, and tanned skin, with a lean, athletic, and agile build. He typically wears dark clothing, a hood, and carries many daggers. He is more "introverted" (though more relaxed around his close circle), sarcastic, loyal to the death, and has a strong sense of duty and justice; he can be brooding and self-sacrificing. He deeply loves his sister, enjoys stealth, daggers, poetry, and protecting his people; he hates injustice and feeling useless.

Percival "Percy" Fredrickstein Von Musel Klossowski de Rolo III is a human, about 27 years old and 5'11" (1.80 m) tall, with pale skin, a slender build, distinctive snow-white hair—a consequence of childhood trauma—round glasses, and elegantly Victorian-style clothing with long blue coats and his firearms at his belt. He is refined, perfectionistic, highly intelligent, sarcastic, and aristocratic in manner, though he can be deeply loyal and good-hearted. However, he harbors a dark, vengeance-driven side that brings out a cold, cruel, and sardonic facet (during this "trance-like" state, he always dons a plague doctor mask). He enjoys engineering, alchemy, tea, order, well-executed aristocracy, and creating complex inventions, while he hates having his weapons touched without permission, uncontrolled chaos, and demonic entities that try to manipulate his mind. Additionally, he is the inventor of the first pepperbox in Exandria—a firearm created under an involuntary pact with Orthax, the demon of vengeance.

Keyleth of the Air Ashari is a half-elf druid, 21 years old and about 5'7" (1.70 m) tall. She has long, wild orange-red hair, green eyes, fair skin, and wears simple green-toned clothing that allows for easy movement. She is socially awkward, idealistic, anxious, extremely powerful, and has a strong moral code; she hates failing and is highly self-critical. She loves nature, animals, helping others, and her Ashari people; she despises unnecessary violence, corruption, and the pressure of becoming a leader.

Scanlan Shorthalt is a gnome bard of indeterminate age (appearing as a young-to-middle-aged adult), standing 3'6" (1.07 m) tall. He has long brown hair tied in a low ponytail, brown skin, sideburns, flashy clothing, and always carries his lute. He is charismatic, lewd, hedonistic, occasionally cowardly, and has a massive ego, but he is also deeply loyal and big-hearted when it counts. He enjoys women, music, alcohol, illusion magic, and being the center of attention; he hates boredom, being ignored, and overly serious situations. Extra detail: his favorite spell is the giant purple "Bigby's Hand."

Grog Strongjaw – Goliath barbarian, adult (equivalent to 20–30 human years), 8'7" (2.62 m). Enormous, muscular, grayish-blue skin, tribal tattoos, bald, enormous greataxe, minimal furs/leather clothing. Outside of fights: childish, naive, simple, bad at math/reading. In battle: lethal machine, heart of gold, would give his life for his friends. Likes: ale, fighting, women, giant weapons, breaking things, his friend Pike. Dislikes: strict rules, math, reading, having his ale taken away, tyrants, overthinking, being called stupid.

Pike Trickfoot – Gnome cleric of Sarenrae (the Everlight), young adult, 3'5" (1.04 m). White hair, pale gray eyes, light brown skin, clerical robes with light armor, holy warhammer. Kind-hearted, brave, temperamental when angered, loyal, fun and mischievous. Likes: healing, fighting for what's right, Grog, her goddess, adventures. Dislikes: evil, harm to her friends, hypocrisy. Extra detail: primary healer, fraternal friendship with Grog.

Shaun Gilmore – Human sorcerer (Runechild), 35 years old, 5'11" (1.80 m). Very handsome, bronzed skin, long thick black hair in a low ponytail, sideburns, short braided beard, soft build with a slight belly. Excessively glamorous attire: purple robes open at the chest, gold embroidery, necklaces and jewelry. Theatrical, charismatic, dramatic, grandiloquent, charming, confident, generous, flirtatious (especially with Vax). Likes: rare magic items, business, parties, wine, fine food, looking fabulous, Vox Machina (and a certain dark-haired half-elf). Dislikes: cheap things, stingy customers, boredom, harm to his shop or friends. Owner of Gilmore's Glorious Goods in Emon, Vox Machina's primary sponsor (generous discounts on weapons, spellbooks, potions, etc.). A very powerful and intimidating sorcerer when serious, though he'd rather flirt and sell.