Killua Zoldyck is one of the main protagonists of Hunter × Hunter. Born into the infamous Zoldyck family of assassins, Killua was raised to become a perfect killer, but he rejects the life chosen for him in search of freedom and genuine friendship. Despite his cool, sarcastic attitude, he's deeply loyal to those he cares about, especially Gon, and gradually learns to trust others and express his emotions. Killua has spiky silver-white hair, striking blue eyes, and a slim, athletic build. He usually wears casual, comfortable clothing such as hoodies, shorts, and sneakers rather than formal attire. Although he often appears relaxed or bored, he's incredibly perceptive, calm under pressure, and possesses exceptional speed, agility, and reflexes. As the series progresses, his Nen ability evolves into a lightning-based power that allows him to move and react at incredible speeds, making him one of the strongest young Hunters in the series.

Gon Freecss is the optimistic and determined protagonist of Hunter × Hunter. Raised on Whale Island by his aunt, Gon sets out to become a Hunter in order to find his father, Ging Freecss, a legendary Hunter who left home when Gon was very young. Cheerful, curious, and fearless, Gon has an infectious enthusiasm and an unwavering belief in his friends. While kind-hearted and compassionate, he can also be incredibly stubborn and reckless, pushing himself far beyond his limits to protect those he cares about or achieve his goals. Gon has messy black hair with green-tinted highlights in the anime, large brown eyes, and a lean, athletic build. He is most often seen wearing a green jacket with red trim, matching green shorts, and sturdy boots. Gifted with extraordinary senses, physical strength, and adaptability, Gon quickly develops into a skilled Nen user. His Nen ability centers on enhancing his natural physical power, allowing him to unleash devastating attacks. Although his bright personality often masks his inner struggles, Gon possesses immense resolve and a fierce determination that make him a formidable Hunter.

Biscuit Krueger, often called Bisky, is a highly skilled Hunter and one of the world's most accomplished Nen masters. Although she usually presents herself as a cute, cheerful young girl, Bisky is actually much older and hides her true muscular physique using Nen. Intelligent, disciplined, and demanding, she has a sharp eye for talent and becomes an invaluable mentor, pushing her students through rigorous training while genuinely caring about their growth. Despite her refined manners and love of cute things, she can be intimidating when serious and never hesitates to punish laziness or carelessness. Bisky has long, blonde hair styled in twin curly pigtails, dark pink eyes, and is most often seen wearing elegant dresses or stylish outfits that complement her youthful appearance. Her true form is tall, heavily muscular, and incredibly powerful, reflecting the immense strength she conceals beneath her Nen ability. As a Transmuter, Bisky possesses exceptional control over Nen and specializes in both combat and training techniques. While she prefers strategy and precision over brute force, her overwhelming experience, physical strength, and mastery of Nen make her one of the strongest Hunters.