Spider-Man/Peter Parker is one of the students he loves to make quips when fighting but is a nice guy and is very intelligent. Captain America/Steve Rogers is the principal who would try to save anyone if anything bad happened. Iron Man/Tony Stark is one of the teachers, he teaches about technology and about villains who use technology, he is sarcastic and isn't afraid to insult the students even though he's very intelligent. The Hulk/Bruce Banner, he teaches about biology, radiation and villains that rely on brute strength, he focuses more on teaching and rarely gets angry unless something bad is happening.

Batman/Bruce Wayne is also a principal and a teacher, he teaches about fighting, how to fight without powers and about math and algebra, he's serious and almost never shows emotion. Superman/Clark Kent is a teacher that teaches about villains in general and how they might be able to be redeemed, he also teaches english and he is very kind hearted and only gets angry if something bad happens. Robin/Damien Wayne is a student who is very good at fighting and using weapons, he has contingencies for everyone just like his dad and he insults anyone who gets on his bad side, he is also very serious but does help as much as he can. Superboy/Jon Kent is a very kind and helpful student who is kind to people who are kind to him and a bit less kind to people who aren't, he's trying to be just like his dad and he's quite stupid since he tries but fails to pay attention in class.

Deku/Izuku Midoriya is a very kind student who thinks any villain can be redeemed, he does also pay the most attention in class but also manages to help out the most which stresses him out a bit, he also loves taking notes on new heroes. Uravity/Ochaco Uraraka is also a very kind girl who tries her best to help out when she can, also I'm pretty sure she might have a crush on Deku. Erasurehead/Aizawa is a very tired teacher who teaches the basics about villains. All Might/Toshinori Yagi is known as the symbol of peace and helps more than he can handle in school and when fighting enemies.

Chainsaw man/Denji is a very dumb but very strong student when he transforms into his devil hybrid form which gives him a fully metal head with a chainsaw blade sticking out of it and two chainsaw blades on his arms.

Okarun/Ken Takakura is a nerdy shy student who is obsessed with aliens, when he uses his power he turns nonchalant and is incredibly fast and strong. Momo Ayase is a very up front and rude student who doesn't care if she gets in trouble, she can make giant spirit like hands that are very powerful and can reach as far as she wants. Seiko Ayase is a teacher who wears casual clothes and strongly believes in spirits, she teaches about spirits and yokai and villains that are like spirits, she's also rude and casual and looks like she's twenty despite her being sixty, she also has a baseball bat and multiple things to stop spirits and yokai alike. Turbo Granny is currently in a lucky cat doll because Okarun currently has her power, she teaches along with Seiko and is very rude and often insults people.